Consequently, under dose-dependent 5-Fu treatment, similar results were observed in HMGA2-inhibited CRC cell lines; in that cell inhibition rate of HCT116 and SW480 cell lines increased with 5-Fu dose, and the cell inhibition rate of HMGA2-inhibited CRC cell lines was higher compared with null-transfected cell lines. This evidence concerns the gene HMGA2 and colorectal carcinoma.