In conclusion, this meta-analysis with published data suggested that the MMP-2-753 C/T, MMP-3-1171 A5/A6, and MMP-9-1562 C/T polymorphisms were associated with periodontitis susceptibility and there is lack of association between the MMP-8-799 C/T polymorphism and periodontitis. This evidence concerns the gene MMP8 and periodontitis.