IGFBP4 and acute respiratory distress syndrome: Levels of BMP-15, IGFBP-4, glypican 3, IL-22BP, IL-5, leptin, or orexin B in SP-ARDS patients gradually and significantly increased by time as compared with the previous day and from day 1 or day 3 and on as compared with controls or SP alone (Figs. 1 and 2, P < 0.05 or less, respectively).