Molecular mechanisms by which selected disease-specific biomarkers may contribute to the development of ARDS as well as tumorigenesis of lung cancer mainly include alterations of cell motility (CXCR3, Supplement Fig. 2), cytokine production, cell adhesion or differentiation (IL-5, IL-5 R alpha, Supplement Fig. 3), survival and migration (CXCL16, Supplement Fig. 4), metabolism (leptin or orexin B, Supplement Fig. 5 or 6), or cell proliferation and adhesion (NOV/CCN3 or IGFBP-4, Supplement Fig. 7 or 8). This evidence concerns the gene IGFBP4 and lung cancer.