CCN3 and acute respiratory distress syndrome: The present study investigated networks of selected ARDS-specific inflammatory mediators, e.g., BMP-15, CXCL16, CXCR3, IL-6, NOV/CCN3, glypican 3, IGFBP-4, IL-5, IL-5 R alpha, IL-22 BP, leptin, MIP-1d, or orexin B, and suggested disease-specific biomarkers as explained in Supplement Figs. 1–11.