IL6 and acute respiratory distress syndrome: The GO biological processes of up-expressed genes mainly included immune response, monocyte chemotaxis, negative regulation of chemokine biosynthesis, neutrophil apoptosis, hepatic immune response, IL-6-mediated signaling pathway, negative regulation of collagen biosynthetic process, inflammatory response, positive regulation of peptidyl-tyrosine phosphorylation, and chemotaxis in SP-ARDS patients (Fig. 4b).