PIK3CA and neoplasm: Amongst other miRs that we already showed to orchestrate a potent EMT/MET-driving network which impacts on metastasis15, this algorithm yielded miRs-134 and -370 as the most significant hits, and we were able to show that these two miRNAs directly target EGFR and PIK3CA and in the process modulate both the PI3K/AKT/mTOR and Raf/MEK/ERK pathways with subsequent effects on tumor growth, proliferation, migration and invasion.