REN and heart failure: Although large amounts of references showed that heart failure was closely related to HIF-1 signaling pathway36, Calcium signaling pathway37, cGMP-PKG signaling pathway38, mTOR signaling pathway39, Renin-angiotensin system40, ErbB signaling pathway41, AMPK signaling pathway42, VEGF signaling pathway43, Vascular smooth muscle contraction44, Adrenergic signaling in cardiomyocytes45 and Estrogen signaling pathway46, further experiments are still needed to identify the relationship between SND and these 11 pathways.