GNRH1 and Miyoshi myopathy: The genes involved in specific pathways regarding the proteasome inhibitors, and particularly bortezomib, are related to the critical pathological events of MM such as tumor angiogenesis and neoplastic signaling pathways (cadherin, integrin, Wnt, GnRH, ubiquitin), as well as chemokine-mediated inflammation (Table 1).