INS and Insulin resistance: Remarkably, the insulin-induced phosphorylation of protein kinase B (PKB) was significantly reduced in the liver of PHD1−/− compared to WT mice on LFD (Fig. 3C,D) whereas no significant effects were observed in eWAT and skeletal muscle (Fig. 3E–H), indicating that the alteration of systemic insulin sensitivity in LFD-fed PHD1−/− mice was mostly due to hepatic insulin resistance.