An increasing trend in the galactomannan antigen seropositivity rate from PA (24.1%) to CPA (35.7%) to IPA (54.9%) and an opposite trend for anti-Aspergillus antibody PA (71.0%) to CPA (45.8%) to IPA (7.1%) were observed (Table 2). The gene discussed is CPA1; the disease is Ito hypomelanosis.