We performed pooled DNA-targeted deep-sequencing of the protein-coding regions of 7 genes, including 5 genes previously reported to most frequently cause familial forms of PD (SNCA, LRRK2, DJ-1, PARK2 and PINK1) and 2 genes that have significant associations in GWAS with sporadic PD (GBA and MAPT genes) in 478 PD patients and 337 healthy individuals of European-American descent from the Washington University in Saint Louis Movement Disorder Clinic (Table 1) [15, 21]. The gene discussed is SNCA; the disease is late-onset Parkinson disease.