LRRK2 and late-onset Parkinson disease: We also found a significant enrichment of coding variants in the LRRK2 gene in PD cases compared to controls (p = 0.01, OR = 1.86, 95 % CI = 1.14-3.02) (Table 6), which suggests that there are other risk variants in the LRRK2 gene in addition to the known pathogenic p.G2019S mutation.