IFNA1 and systemic lupus erythematosus: One important mechanism of IFN-α induction in SLE is mediated by interferogenic ICs, which are immune complexes consisting of autoantibodies and nucleic acid-binding proteins that are endocytosed through FcγRIIa on pDCs and transported into the endosomes where the nucleic acid part of the IC interacts with TLR7 or TLR9 [19, 20].