CRTC1 and Alzheimer disease: Interestingly, CRTC1 mRNA expression showed a trend to be inversely correlated with Prom1 methylation levels (rSpearman = −0.949, p = 0.051) in the control group; meanwhile, no significant correlation was found between methylation and expression among AD patients (rSpearman = −0.287, p = 0.490).