The V600 mutations account for the majority of BRAF mutations and are observed in Langerhans cell histiocytosis (LCH) [4], Erdheim-Chester disease (ECD) [5], melanoma [6], papillary thyroid carcinoma [7, 8], colorectal cancer [9], hairy cell leukemia (HCL) [10], and chronic lymphocytic leukemia (CLL) [11]. This evidence concerns the gene BRAF and Langerhans cell histiocytosis.