Given these properties, NLRP3 not surprisingly has been implicated in the pathogenesis of numerous kidney diseases at the experimental level including ischemia/reperfusion injury, unilateral ureteric obstruction, diabetic nephropathy, calcium oxalate-induced renal injury, diet-induced nephropathy and hyperhomocysteinemia3, 6, 8, 9, 10, 11, 12, 13. This evidence concerns the gene NLRP3 and kidney disorder.