The top 5 up-regulated genes based upon fold change between groups were: carbamoyl-phosphate synthase 1 (CPS1), carboxypeptidase O (CPO), tubulointerstitial nephritis antigen (TINAG), solute carrier family 7, member 9 (SLC7A9), and solute carrier family 6, member 19 (SLC6A19). The gene discussed is CPO; the disease is nephritis.