Consequently, inhibition or depletion of OSBP inhibits replication of enteroviruses and cardioviruses; however, OSBP is not required by all picornaviruses and infections by equine rhinitis A virus (ERAV; genus Aphthovirus) and human parechoviruses (genus Parechovirus) are OSBP independent (Strating et al., 2015). This evidence concerns the gene OSBP and infection.