To determine whether SFN requires Nrf2 to impair HIV infection of macrophages, we depleted primary hMDMs of Nrf2 with siRNA and assessed the impact of this treatment on infection with VSV-G-pseudotyped HIV-1 luciferase reporter virus, both in the presence and absence of 10 μM SFN. The gene discussed is NFE2L2; the disease is infection.