The data showed that the levels of miR-182, miR-183, and miR-210 were significantly distinct between NSCLC patients and tobacco smokers, with AUCs of 0.764, 0.781, and 0.714; sensitivities of 71.4%, 71.4%, and 50.9%; and specificities of 90.0%, 80.0%, and 90.0%, respectively (P < 0.0001, < 0.0001, and 0.0001; 95% CI: 0.683–0.834, 0.701–0.848, and 0.629–0.789; Fig 5), whereas the levels of miR126 and CEA had no obvious difference in AUCs to distinguish NSCLC and tobacco smokers (P = 0.1322, 0.5053; Fig 5). Here, CEACAM5 is linked to non-small cell lung carcinoma.