Mutations identified in previous SCLC genomic studies shared little consensus for significantly mutated genes other than TP53 and RB1. However, by leveraging our data with these previous SCLC studies, we were able to identify three additional common significantly mutated genes (TMEM132D, NCAM2, and CDH10) with over 10% prevalence in SCLC. The gene discussed is TP53; the disease is small cell lung carcinoma.