Since it recently has been shown that ZIKV is highly sensitive to the antiviral effects of type I and II interferons (IFN) [18] and that type I and II IFNs control replication and dissemination of many viruses, including other flaviviruses [19–23], we hypothesized that IFN-deficient mice would be susceptible to wild-type ZIKV infection. Here, IFNA1 is linked to Zika virus infectious disease.