These have been related to regulation of inhibitory interneuron circuits in sensory cortex, which act to bind stimulus features.24 Time–frequency analyses of evoked EEG data to our knowledge have not been conducted in FXS, but may be useful to investigate neural correlates of local circuit hyper-excitability, particularly in the gamma range where deficits have been observed in Fmr1 mice and proposed to underlie sensory processing abnormalities.5 This evidence concerns the gene FMR1 and fragile X syndrome.