WFS1 and mental disorder: Apolipoprotein D (APOD) is associated to T2D,99 but its implicated role in SCZ is not confirmed in all studies.100 Wolfram syndrome 1 (WFS1) confers risk to T2D,101 and, despite high mental disorder prevalence (but not SCZ) in patients with Wolfram syndrome, WFS1 role in SCZ is not supported.102, 103