CFTR and cystic fibrosis: This proposal is supported by a two-hybrid screening analysis which showed that the N- and C- regions of KCa3.1 interact with NBD2 and C-terminal regions of CFTR respectively, coupled to results from co-immunoprecipitation experiments indicating that wt-CFTR and F508del-CFTR form an immunoprecipitable complex with KCa3.1 in native non-CF and CF airway epithelial CFBE cells.