The example of sample P1 in Figure 3 (low cytotoxicity of ABT-199 coupled with low NOXA-BH3 priming, as with the OCI-AML-3 cells) suggests that, at the concentrations used, the peptides are not triggering MOMP in their own right, but prime the cells to release Cytochrome C in the presence of an appropriate trigger of a complementary pathway. Here, PMAIP1 is linked to acute myeloid leukemia.