We also show that upon tumor cell opsonisation and/or the disruption of CD47-SIRPa interactions by blocking anti-CD47 treatment, the in vivo tumor microenvironment reflects a potentially beneficial M1-dominant profile, strongly suggesting either the re-education of M2 TAMs into M1 macrophages or the enhanced recruitment of M1 macrophages from the periphery is occurring in this setting. Here, SIRPA is linked to neoplasm.