It has also been reported that the binding of CrkL to phosphorylated form of signal transducer and activator of transcription (STAT5) leads to translocation of the complex into the nucleus where it binds to the promoter region of c-Abl or Bcr-Abl genes in chronic myeloid leukemia (CML) cells [33,34]. The gene discussed is CRKL; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.