The effects of the substances contained in M. speciosa extract (alkaloids, saponins, flavonoids, etc.) have not yet been well researched making the correlation between the health of the liver and the intake of these preparations very difficult: for example only recently Azizi et al. [168] demonstrated a correlation between the administration of M. speciosa extracts in mice and the increased level of glutathione-S-transferase, as a possible sign of hepatic disease. This evidence concerns the gene HPGDS and liver disorder.