AKT1 and neoplasm: These mechanisms include antibody-dependent cell-mediated cytotoxicity (ADCC), the inhibition of downstream substrates, the activation of variety of signaling cascades, including the phosphatidylinositol-3 kinase (PI3K)/serine/threonine-specific protein kinase (Akt) pathway, the induction of cell cycle arrest and apoptosis or the inhibition of tumor angiogenesis [8,9].