In another category of liver regeneration after partial hepatectomy, Boermeester et al. showed that, using IL-1Ra to antagonize 2/3 partial hepatectomy (PH) rat-derived IL-1, residual liver inflammation was significantly reduced and the number of PCNA-positive cells was significantly increased, indicating that IL-1-mediated liver inflammation is an important factor in 2/3 PH rat liver failure [33]. The gene discussed is IL1B; the disease is liver failure.