On the other hand, there was a significant and positive correlation among endothelium-related changes in myocardial blood flow and elevated leptin and CRP, respectively, in morbidly obese individuals that was not observed for endocannabinoid anandamide, suggesting a difference between obesity and morbid obesity (as different entities) in affecting coronary circulatory function [26]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.