KALRN and attention deficit-hyperactivity disorder: In humans, kalirin has been associated with a number of disorders in which impulsiveness is a feature (Remmers et al., 2014), including ADHD (Lesch et al., 2008), a condition characterized by lowered impulse control, that is also associated with altered frontal cortical control of striatal function (Robbins, 2007; Cubillo et al., 2012; Whelan et al., 2012).