Given that overexpression of Cyclin D1 is directly linked to development of cancer development through integrating the control of pRb phosphorylation with the transcriptional activity of E2F transcription factors, targeting Cyclin D1 degradation would offer as a potential therapeutic mechanism in EBV associated B-cell lymphomas, where EBNA-3C is expressed. This evidence concerns the gene CCND1 and B-cell non-Hodgkin lymphoma.