Nonetheless, EBNA-3C substantially antagonizes ING4 and ING5 promoted p53 mediated ant-proliferative activities possibly through blocking the interaction of ING proteins with p53 (Saha et al., 2011a) and thus restoration of ING functions in order to activate p53 induced apoptosis offers a potential therapeutic approach against EBV associated B-cell lymphomas. The gene discussed is TP53; the disease is B-cell non-Hodgkin lymphoma.