In addition to modifying HAT and HDAC activities, EBNA-3 proteins precisely EBNA-3A and -3C were also shown to recruit DNA-methyltransferase (DNMT) activity in order to suppress Bim (BCL2L11) tumor suppressor expression in Burkitt's lymphoma cells (Anderton et al., 2008; Paschos et al., 2009) (discussed in more details in later section). Here, BCL2L11 is linked to neoplasm.