The RhoA/ROCK pathway is activated by several hypertension-associated factors, such as the Ang II (Carbone et al., 2015), endothelin-1 (Et-1; Homma et al., 2007), leptin (Zeidan et al., 2007), and mechanical stretch (Zeidan et al., 2003). The gene discussed is EDN1; the disease is hypertensive disorder.