GFAP and Alzheimer disease: It is well-established that Aβ plaques are surrounded by reactive GFAP+ astrocytes in AD mouse brains (Nagele et al., 2004; Olabarria et al., 2010; Daschil et al., 2013, 2015; Serrano-Pozo et al., 2013; Rodríguez-Arellano et al., 2015).