Alzheimer’s disease (AD) comes along with a severe cognitive decline and is characterized by the extracellular deposition of beta-amyloid (Aβ) plaques, intraneuronal Tau pathology, synaptic loss resulting in cholinergic neuronal cell death and inflammatory processes such as the activation of astrocytes and microglia (Selkoe, 2001). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.