GRHL3 and epilepsy: In both animal epilepsy models and humans with spontaneous seizures, certain subtypes of dentate GABAergic interneurons, especially those somatostatin (SOM)- and parvalbumin (PV)-expressing cells are reduced (Sloviter, 1987; de Lanerolle et al., 1989; Schwarzer et al., 1995; Morin et al., 1998; Gorter et al., 2001; Sundstrom et al., 2001; Sun et al., 2007; Kuruba et al., 2011).