In addition, TAAR1 KO exhibited significant deficits in sensorimotor gating measured as impaired prepulse inhibition of acoustic startle (Wolinsky et al., 2007), which is a known behavioral signature in schizophrenia regulated by both dopaminergic and glutamatergic mechanisms (Wan et al., 1995; Wan and Swerdlow, 1996; Geyer et al., 2001). Here, TAAR1 is linked to schizophrenia.