TAAR1 and hyperinsulinemic hypoglycemia, familial, 4: Interestingly, selective activation of TAAR1 by both full and partial agonists has been shown to reverse glutamatergic hypofunction induced by selective NMDA receptor antagonists in wild-type animals and mutant mice with NMDA receptor deficiency (Revel et al., 2011, 2012a, 2013), suggesting that TAAR1 activation may enhance glutamatergic function.