4. TAAR1 KO mice showed altered structure and function of cortical NMDA receptors, accompanied with behavioral perseveration and impulsivity; TAAR1 full, and partial agonists reversed pharmacologically- or genetically-induced glutamatergic hypofunction and reduced impulsivity in normal mice, consistent with a hypoglutamatergic hypothesis of schizophrenia. The gene discussed is TAAR1; the disease is schizophrenia.