GSK3B and schizophrenia: In addition, dysregulation of the β-arrestin2/AKT/GSK3β pathway has been implicated in schizophrenia and a wide range of clinically effective antipsychotics were shown to antagonize D2 receptor-mediated β-arrestin2 signaling and inhibit GSK3β activity (Masri et al., 2008; Beaulieu et al., 2009; Emamian, 2012; Urs et al., 2012).