LHB and major depressive disorder: More recent studies in humans have corroborated the notion of LHb involvement in the reward system (Salas et al., 2010), and, interestingly, two case reports have since been published (2010, 2013) showing remission of major depression under DBS of the LHb (Sartorius et al., 2010; Kiening and Sartorius, 2013; Schneider et al., 2013).