RET and nonpapillary renal cell carcinoma: Moreover, the cytoplasmic RET expression was an independent predictor of PFS (2.203, 1.598 to 3.039, p < 0.001) and OS (1.928, 1.402 to 2.650, p < 0.001) in metastatic ccRCC (Figures 3(e) and 3(f)).