In this case, we have to be careful and take into account that those patients developing toxicity to the first-line treatment would not be candidates to a second-line with OXA and iii) the measurement of CXCL1 (and probably CXCL8) in tumours (but also in serum) could serve to identify those patients that are more likely to respond to OXA + Curcumin. This evidence concerns the gene CXCL8 and neoplasm.