NFKB1 and colorectal carcinoma: The role of elevated NF-κB activity in the resistance of CRC cells to OXA-induced cell death was previously demonstrated30 and in agreement with other studies40, results presented here indicate that NF-κB is constitutively active in all the CRC cell lines examined; however, we found that those cell lines with acquired resistance to OXA exhibited an increased activation of this pathway as compared to their matched sensitive parental cells, especially the HTOXAR3 resistant model, suggesting a role for NF-κB and its downstream targets in the development of the drug-resistant phenotype.