NF-κB is a transcription factor that contributes to the progression of CRC by regulating the expression of diverse target genes that are involved in inflammation (e.g. TNFα, IL-1, CXC-chemokines), cell proliferation (e.g. Cyclin D1, COX2, c-myc, IL-6), apoptosis (e.g. XIAP, IAP-1, IAP-2, Survivin, Bcl-2 and Bcl-xl), angiogenesis (e.g. VEGF, IL-8), invasion (e.g. ICAM-1, VCAM-1) and metastasis (e.g. MMP-9)6. Here, CXCL8 is linked to colorectal carcinoma.