Although the heparanase activity was not significantly higher in the urine of patients with FSGS, the heparanase in urine was correlated with heparanase in serum (r = 0.7; p = 0.001), heparanase in granulocytes (r = 0.69; p = 0.006), and dismutase in granulocytes (r = 0.6; p = 0.02), in this group of patients. Here, HPSE is linked to focal segmental glomerulosclerosis.