Correlations between heparanase activity in urine and dsDNA antibodies (r = −0.51; p = 0.04; Fig. 1), and between heparanase in urine and hemolytic activity of the complement (r = −0.57; p = 0.03; Fig. 2) in the lupus nephritis group were found. This evidence concerns the gene HPSE and lupus nephritis.