Further, the literature survey showed that out of these 40% proteins, 12 proteins are lung cancer related biomarkers, which includes Annexin family members (Annexin A1, A2, A3, A5, A6, A11), Nitrogen permease regulator 2-like protein (NPRL2), Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), Mucin 1 (MUC1), Prominin-1 (PROM1), Histone H4 (HIST1H4A), and Tumor necrosis factor alpha-induced protein 3 (TNFAIP3). This evidence concerns the gene NPRL2 and lung cancer.