In the studies by Savastano et al. in 48 subjects9 and Kotronen et al. in 113 subjects7, the correlation coefficients between fS-IGFBP-1 and hepatic steatosis score (ultrasound) or liver fat (1H-MRS) were in both studies −0.38 (P < 0.01 or less). This evidence concerns the gene IGFBP1 and Hepatic steatosis.