Females in the oldest age category (>78 years) showed a similar association of C4A copy number with AMD in the conditioned and in the unconditioned model (OR unconditioned on CFB/C2 variants: 0.62 (0.48; 0.79), OR conditioned on CFB/C2 variants: 0.68 (0.52; 0.90)). The gene discussed is CFB; the disease is age-related macular degeneration.