Relating to possible nutrients of oily fish involved in their beneficial effects, because of omega 3 fatty acids supplements failed to yield changes in insulin metabolism in T2D patients [5], some authors emphasized that other nutrients [20], including oily fish protein and taurine (especially in sardines) could have a role in their insulin sensitive effects, as some studies showed in animal models with diabetes and metabolic syndrome [6, 7]. Here, INS is linked to diabetes mellitus.