This type of method would be especially beneficial for understanding complex brain diseases such as Alzheimer’s disease (AD), which involve simultaneous pathological events including neuronal dysmorphism, β-amyloid1−42 (now referred to as Aβ) plaque deposition, neurofibrillary tangle accumulation, hyper-phosphorylation of tau, as well as, glial reactivity and neuroinflammation4. The gene discussed is MAPT; the disease is Alzheimer disease.