These four mechanisms—MYC genomic gain (9% of O1 tumours), MAX genomic loss (35% of O1 tumours), MYC exon 3 hypomethylation (20% of O1 tumours) and mir34b/c locus hypermethylation (28% of O1 tumours)—were not all required to observe an increase of MYC activity. The gene discussed is MYC; the disease is neoplasm.