Based on these results, several natural and artificial Nrf2 activators are being evaluated in the treatment of diabetic CKD patients in the “Bardoxolone ethyl and kidney function in CKD with type 2 diabetes (BEAM)” study and previously in the “Bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes: the occurrence of renal events (BEACON)” trial [64,65]. The gene discussed is NFE2L2; the disease is type 2 diabetes mellitus.