Activated caspases have been detected in different model systems in a non-apoptotic manner.18, 19, 22, 23 Elevated levels of CASP7 have been reported to be associated with moderate and well-differentiated tumors in OSCC.24 As CASP7 was essential for proliferation and cell growth18, 19 and its expression in primary breast carcinoma showed no correlation with rate of apoptosis;22 we hypothesize that CASP7 may mediate some non-apoptotic function-like cell proliferation in the breast cancer cells. This evidence concerns the gene CASP7 and breast carcinoma.