CASP7 and breast cancer: The localization of active form of CASP7 was speculated previously in the nucleus to regulate cell cycle progression, which the authors did not confirm its presence.19 In our present study we could detect the active form of CASP7 by immunofluorescence in the nucleus of MCF7 and T47D cell lines but its presence was hardly detected in the nucleus during fractionation assay of breast cancer cells, which might be probably due to levels lower in the nucleus than in cytoplasm.