Mice that had bone fracture 6-hours before pMCAO also had more bone marrow-derived macrophages (40.4±9.78% of DAPI labeled nuclei, CCR2+) in the peri-infarct regions compared to stroke-only mice (24.4±5.15%, p = 0.001) and bone fracture 24 hours before pMCAO mice (24.0±5.57%, p = 0.001, Fig 6B & 6D). This evidence concerns the gene CCR2 and stroke disorder.