Macrophages and lymphocytes infiltrate the interstitium in angiotensin II-induced hypertension [41], where T cells increase in the adventitia of blood vessels and secrete cytokines such as tumor necrosis factor-α (TNF-α) and IL-17 as well as NADPH oxidase [43, 45], which then lead to elevated blood pressure. The gene discussed is TNF; the disease is hypertensive disorder.