Among them, Sombroek and collaborators demonstrated that primary tumors (renal carcinoma, cervical cancer, breast cancer and melanoma) negatively modulate the development and activity of dendritic cells through factors regulated by cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) [50]. The gene discussed is PTGS2; the disease is cervical carcinoma.